Is mefenamic acid acidic?
Mefenamic Acid is an anthranilic acid and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities.
What is the pKa of paracetamol?
A number of common drugs contain the phenol functional group. These include paracetamol (pKa 9.5), morphine (pKa 9.9) and levothyroxine (thy- roxine) (pKa 10).
What is the frequency of mefenamic acid?
Adult dosage (ages 18 years and older) The first dose is 500 mg. After that, take 250 mg every six hours as needed. You shouldn’t take mefenamic acid for longer than three days.
What is the classification of mefenamic acid?
Mefenamic acid is in a class of medications called NSAIDs. It works by stopping the body’s production of a substance that causes pain, fever, and inflammation.
Is mefenamic acid soluble in water?
Mefenamic acid has poor solubility in water of which range spanned from approximately 0,004 mg/mL (37 °C [9]) to 0.2 mg/mL (25 °C [10]).
What is the pKa of ibuprofen?
Ibuprofen has a pKa of 4.43±0.03 and an n-octanol/water partition coefficient of 11.7 at pH 7.4. The chemical name for ibuprofen is (±)-2-(p-isobutylphenyl) propionic acid. The molecular weight of ibuprofen is 206.28.
What is pKa of a drug?
The pKa of a drug is the hydrogen ion concentration (pH) at which 50% of the drug exists in its ionized hydrophilic form (i.e., in equilibrium with its un-ionized lipophilic form). All local anesthetic agents are weak bases. At physiologic pH, the lower the pKa the greater the lipophilicity.
Can I take 2 500mg mefenamic acid?
The first dose is 500 mg. After that, take 250 mg every 6 hours as needed. You shouldn’t take mefenamic acid for longer than 2–3 days.
Can I take mefenamic 3 times a day?
The usual dose is 500 mg, which is taken as two 250 mg capsules, or one 500 mg tablet. You will be asked to take this dose three times a day. If you are taking it for period pain, your doctor will likely suggest that you take it for a few days each month, starting on your first day of bleeding.
How strong is mefenamic acid?
Take mefenamic acid exactly as your doctor tells you to. The usual dose is 500 mg, which is taken as two 250 mg capsules, or one 500 mg tablet.
What is the difference between Fenamic acid and mefenamic acid?
Analogous to fenamic acid, this compound may be made from 2-chlorobenzoic acid and 2,3-dimethylaniline. Mefenamic acid is generic and is available worldwide under many brand names.
What are the side effects of mefenamic acid?
Known mild side effects of mefenamic acid include headaches, nervousness, and vomiting. Serious side effects may include diarrhea, hematemesis (vomiting blood), hematuria (blood in urine), blurred vision, skin rash, itching and swelling, sore throat and fever.
What is the structure of Meclofenamic acid?
Meclofenamic acid is an aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,6-dichloro-3-methylphenyl group. A non-steroidal anti-inflammatory drug, it is used as the sodium salt for the treatment of dysmenorrhoea (painful periods),…
How does mefenamic acid inhibit prostaglandin synthesis?
Mefenamic acid inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis, by prostaglandin synthase, is responsible for the therapeutic effects of mefenamic acid.