What does HER3 positive mean?

What does HER3 positive mean?

HER3 is emerging as a crucial biomarker in luminal breast cancers. HER3 mRNA is expressed significantly in estrogen receptor positive (ER+) or luminal tumors, consistent with the observation that HER3 is essential for cell survival in the luminal but not the basal normal mammary epithelium.

What is HER3 gene?

Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene.

Is HER3 an oncogene?

HER3 lacks or has little intrinsic tyrosine kinase activity, but it frequently co-expresses and forms heterodimers with other receptor tyrosine kinases (RTKs) to activate oncogenic signaling in cancer cells.

What is EGFR gene?

EGFR (epidermal growth factor receptor) is a protein on cells that helps them grow. A mutation in the gene for EGFR can make it grow too much, which can cause cancer. There are different types of EGFR mutations.

What is ERBB2 gene?

ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2, also known as HER2 and neu) is a gene that encodes for the receptor tyrosine-protein kinase erbB-2. ERBB2 has been found to be amplified with an increased copy number in several cancers (PMID: 20185938).

What is her 2 neu gene?

Listen to pronunciation. A protein involved in normal cell growth. HER2/neu may be made in larger than normal amounts by some types of cancer cells, including breast, ovarian, bladder, pancreatic, and stomach cancers. This may cause cancer cells to grow more quickly and spread to other parts of the body.

What is the mechanism of action for gefitinib and erlotinib?

The TKIs erlotinib and gefitinib and the monoclonal antibody cetuximab share a common target, the EGFR. Although the precise mechanism of action may differ between these two classes of drugs, each ultimately inhibits EGFR signaling and the related downstream biologic effects.