What is the pathophysiology of obstructive jaundice?
Obstructive jaundice is a specific type of jaundice, where symptoms develop due to a narrowed or blocked bile duct or pancreatic duct, preventing the normal drainage of bile from the bloodstream into the intestines.
What is obstructive jaundice PDF?
Obstructive jaundice results from obstruction to the. free flow of bile from the liver to the gall bladder and then. to the small intestine. Jaundice or raised total bilirubin may be. due to an increase in either conjugated or unconjugated compo-
What are the characteristics of obstructive jaundice?
Yellowing of the skin and whites of the eyes, light-coloured stools and dark urine could be signs of obstructive jaundice – a condition where normal drainage of bile from the liver to the small intestines is blocked.
What is the treatment of obstructive jaundice?
Treatment of obstructive jaundice If gallstones are diagnosed, endoscopic removal of the stones obstructing the bile duct is recommended. Endoscopic stenting is sometimes necessary as a temporary measure to relieve the bile duct obstruction and clear any bacterial infection before definitive surgery.
Why Vit K is given in obstructive jaundice?
In obstructive jaundice, mal-absorption of vitamin K results in hypoprothrombinaemia and a fall in the concentration of the other vitamin K-dependent pro- and anticoagulation factors. Laboratory assays are used to assess the state of the coagulation system.
What enzymes increase in obstructive jaundice?
The activity of enzymes, such as alkaline phosphatase, gamma-glutamyl transpeptidase, and leicine aminopeptidase, was found to be increased in the serum and tear of 28 patients with obstructive jaundice.
Why is alkaline phosphatase elevated in obstructive jaundice?
Bile duct obstruction results in increased synthesis of ALP by bile duct epithelial cells and release of ALP into the serum. Alkaline phosphatase may be increased even if only a few small bile ducts are obstructed, and serum bilirubin is normal.
Why does GGT increase in obstructive jaundice?
Conversely, because the GGT is more specifically related to the liver, an elevated GGT with an elevated ALP would strengthen the diagnosis of liver or bile-duct disease. Therefore, raised serum level of GGT can be used as a diagnostic marker in patients of CBD obstruction along with alkaline phosphatse.